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Is it safe to start immunotherapy concurrently with radiation to a bone metastases?

In a patient being treated with a palliative course of radiation for a bony metastasis from lung cancer is it safe to start immunotherapy for POD or would it be preferable to wait until radiation is completed?
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What is your practice with respect to timing of immunotherapy and radiation

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2 Answers
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Mednet MemberInvited Expert
Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on

Retrospective data for palliative RT and immunotherapy doesn’t suggest increased complications with concurrent use

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Mednet Member
Mednet Member
Radiation Oncology · Florida Cancer Affiliates / The US Oncology Network
Answered on · Updated on

Great question!

This depends on the unique clinical situation with respect to dose, fractionation, and field size. Radiation therapy and immunotherapy in partnership may have the capability of delivering a therapeutic effect exceeding the sum of its parts. The possible relationship has now been demo...

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