Is keratosis follicularis (Darier disease) a contraindication to the receipt of PMRT?

A postmenopausal patient underwent surgery, MRM for an ER-negative, PR-negative, HER2-negative, pT2N0(sn) invasive ductal carcinoma of the breast. Positive surgical margins were present after surgery, which could not be re-resected to obtain negative margins.

Would you offer PMRT to this patient if they also were known to have keratosis follicularis (Darier disease) - a genodermatosis caused by mutations in the ATP2A2 gene?

Answer from: Radiation Oncologist at Academic Institution

Thanks for this interesting question. It prompted me to do a bit of literature search and think about how I'd approach this case.For a postmenopausal patient with ER-negative, PR-negative, HER2-negative (triple-negative) pT2N0(sn) breast cancer and unresectable positive surgical margi...

Comments

Radiation Oncologist at Memorial Sloan-Kettering Cancer Center
Drs. @Corbin and @Anderson, since the PMRT is give...

Radiation Oncologist at Northside Hospital
I agree with Dr. @Corbin's assessment regarding an...

Answer from: Radiation Oncologist at Community Practice

Yes.

Please select the option that best describes you:

Is keratosis follicularis (Darier disease) a contraindication to the receipt of PMRT?

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