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Is keratosis follicularis (Darier disease) a contraindication to the receipt of PMRT?

A postmenopausal patient underwent surgery, MRM for an ER-negative, PR-negative, HER2-negative, pT2N0(sn) invasive ductal carcinoma of the breast. Positive surgical margins were present after surgery, which could not be re-resected to obtain negative margins. Would you offer PMRT to this patient if they also were known to have keratosis follicularis (Darier disease) - a genodermatosis caused by mutations in the ATP2A2 gene?
2 Answers
Mednet Member
Mednet MemberInvited Expert
Radiation Oncology · Mayo Clinic Hospital
Answered on · Updated on

Thanks for this interesting question. It prompted me to do a bit of literature search and think about how I'd approach this case.

For a postmenopausal patient with ER-negative, PR-negative, HER2-negative (triple-negative) pT2N0(sn) breast cancer and unresectable positive surgical margins after mastec...

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Mednet Member
Mednet Member
Radiation Oncology · Comprehensive Cancer Centers of Nevada
Answered on

Yes.

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