Is the PROTEUS data enough to change your practice in the treatment of patients with high-risk localized or locally advanced prostate cancer?

PROTEUS was a phase III RCT initially designed to evaluate if RP/ADT/APA (12 mo peri-op) was better than RT/ADT/Placebo in patients with high-risk localized prostate cancer on the co-primary endpoints of (1) major pathologic response and (2) MFS as adjudicated by blinded independent review of conven...

The question asks if the results of PROTEUS would/should impact practice patterns...let us take a look:

1. ADT is not recommended to be used with radical prostatectomy in prostate cancer by any guideline.
2. Apalutamide or any ARPI are not recommended to be used with RP in prostate cancer in any guideline...