Is the rise in LDL and liver fat after starting tryngolza a concern?

A modest increase in LDL-C after olezarsen (Tryngolza) and plozasiran (Redemplo) have been been reported, particularly in patients with severe hypertriglyceridemia. It probably reflects the conversion of TG-rich LPs and TG-remnants to smaller lipid particles, including IDL and LDL. Notably, the non-...

I agree with Dr. @Dr. First Last - as VLDL TG is lipolyzed, there is more conversion to LDL, so the latter levels may rise. This is most obvious when TG levels are >500-1000 at baseline. But apoB does not increase, or if it does, it is modest. These data suggest that increased hepatic uptake of VLDL...