Is the rise in LDL and liver fat after starting tryngolza a concern?

A modest increase in LDL-C after olezarsen (Tryngolza) and plozasiran (Redemplo) have been been reported, particularly in patients with severe hypertriglyceridemia. It probably reflects the conversion of TG-rich LPs and TG-remnants to smaller lipid particles including IDL and LDL. Notably, the non-H...