I know this question was asked last year, but for the record: Mark makes some great points above, but I respectfully disagree on using irinotecan in the post-met/micrometastatic setting. I don't feel the Ychou study provides enough support for this practice since there was no significant improvement...

For patients who undergo surgery for liver metastasis/oligometastases, adjuvant therapy is typically recommended. When synchronous metastases are resected at the same time as the primary lesion, oxaliplatin-based regimens should be adminstered with attenuated expectation of the DFS and OS benefits s...