Is there a role for biologics to improve lung function in patients who have severe asthma with daily symptoms and reduced lung function but do not experience frequent exacerbations?

Biologic therapy in severe asthma not only reduce exacerbation but also improve lung function based on several RCT.

Asthma is a heterogeneous disease with different phenotypes and treatment should target these phenotypes. Before going down the path of biologics I would optimize treatment for other comorbidities that are known asthma mimickers: ILO, Obesity, GERD, rhinosinusitis, etc. In cases of TH2-driven asthma...