Is there a role for combining weekly cisplatin with EBRT in early glottic cancer?

No role for chemotherapy in T1 glottic ca with anterior commissure involvement (or T2 whose only potential adverse factor is such involvement).

The reasons anterior commissure involvement in T1 glottic cancer is associated in many studies with worse LRR may be undetected involvement of the inner thyr...

It depends on how you define "early".

We have added chemotherapy for bulky T2N0 disease; We mainly do this as the local control rates for T3 disease in the laryngeal preservation RTOG 91-11 seemed comparable to that in the T2 study (RTOG 9512) both in the mid 70's There is a paper from the UF group t...

Assuming T1N0. The short answer is no. We already get good results there. Adding chemo for what reason?

At my institution, we consider adding concurrent chemotherapy for cT2bN0 (i.e., hypomobile cord). This is based on a 2016 study, Impaired vocal cord mobility in T2N0 glottic carcinoma: Suboptimal local control with Radiation alone, by Koyfman and colleagues in Cleveland. This study found worse local...