Is there a role for hyperbaric oxygen treatment concurrent with radiotherapy in the treatment of pediatric glioblastoma?

HBO has been used primarily in the treatment of radiation induced injury in patients with controlled intracranial disease. The application of HBO in the post-treatment setting has been limited by fears of latent reactivation of tumor metabolism and therefore progression. There are countless manuscripts which have shown this effect in vitro with adult type HGG cell lines. Pediatric HGG has an entirely different biology and to my knowledge, there are no data on the effect of HBO + RT in pediatric type HGG.

There are others who have advocated for the use of HBO concurrent with chemoradiotherapy in GBM with the hypothesis that hypoxic regions which are more radioresistant will be reoxygenated thus facilitating increased reactive oxygen species g...