Is there a role for monitoring serum ANCAs to assess ANCA associated vasculitis disease activity?
This question is part of a collaboration with RheumMadness and is in reference to Pathogenic ANCA (RAVE Trial).
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How often do you trend ANCA titers?
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3 Answers
Mednet MemberInvited Expert
Rheumatology · Medical College of Wisconsin Affiliated Hospitals
Answered on · Updated on
This is (and remains) a somewhat controversial question. ANCA titers do appear to rise in anticipation of disease flares and patients with persistent titers appear to have more flares. This is especially true for PR3 ANCAs. However, the proximity of flares to rising ANCA titers is not terribly close...
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Mednet Member
Rheumatology · Valley Children's Healthcare
Answered on
Every visit.
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Mednet Member
Rheumatology · Pacific Northwest University of Health Sciences
Answered on
Each visit, it is a marker to predict disease flare and need to resume rituximab or increase therapy.
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