Is there a role for resection of the cutaneous primary in a patient on dual-agent immunotherapy for metastatic melanoma?

Yes. The location and size (width, length) should be noted. The patient should first be treated with dual ICI. If the patient with metastatic melanoma, who has the primary intact, undergoes successful dual ICI therapy and has a documented CR, near CR, or excellent PR, which is typically noted within...

Not really, unless it is symptomatic and not responding to treatment. In that scenario, a resection with "palliative" intent is sufficient, meaning that the margin need not be 2 cm wide. If the tumor responds, it will mostly leave behind a benign melanocytic lesion. I usually request our dermatology...

There is only a palliative role for surgery in stage IV melanoma. However, if patients end up with oligometastatic disease (i.e., a few isolated liver metastases) after ICI, there may be a role for surgery for selected patients. Patients will still need to be monitored closely, though, after surgery...