Topics:
Thoracic Malignancies • Medical Oncology
Is there a role for temozolomide in patients with Stage IV NSCLC with leptomeningeal disease who have progressed on first line chemo-immunotherapy?
Answer from: Medical Oncologist at Academic Institution
I've tried it and have never been impressed with it. The only treatments that I've ever seen convincingly work for LMD in NSCLC is in patients with actionable mutations treated with brain-penetrating TKIs.
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