I have a lot of experience using this regimen in elderly patients due to the setting where i  practice. In the MPACT trial the oldest patient enrolled was 88 and 10% of patients were aged over 75. I have treated many patients over the age of 85 and even into early 90s if ECOG reasonable. I usua...

I actually have found full dose therapy (1000mg/m2 of gem; 125mg/m2 of abraxane) to be very well tolerated when given on an every other week schedule, which in a retrospective review was as effective as 3 on, 1 off therapy (PMID: 28203300)