Is there any antiresorptive therapy that you would be comfortable prescribing if the patient refuses to see a dentist for clearance and is at risk of skeletal-related events?  

For patients with hypercalcemia of malignancy, I don't usually worry about dental care. For everyone else, short answer is no.The "secret" about anti-resorptive therapy is that it provides clear benefits in patients that have myeloma that is not well-controlled (PMID 8559201, 9469347). Things become...