Is there any data to support the use of hormone therapy with RT in the adjuvant post-prostatectomy setting?

Unfortunately, randomized data remains limited. Although pT3/N1 pts were included in RTOG 8531 (www.ncbi.nlm.nih.gov/pubmed/15817329), the majority of the pts included in this trial were treated with definitive radiation. At ASTRO 2011, Shipley et al reported the results of RTOG 9601 (www.redjournal.org/article/S0360-3016(10)01077-1/fulltext), which randomized pts who were post-prostatectomy and had an elevated PSA w/ + margins, pT3 disease, or + biopsy to salvage RT with or without long-term androgen deprivation in the form of casodex. Although they did note a benefit in distant metastasis, the follow-up (median 7 yrs.) was too short to report survival results. That said, there is retrospective data (from Stanford, MD Anderson) that does s...