Is there any evidence that ivermectin suppresses the PSA level in prostate cancer?

I had two prostate cancer patients recently take ivermectin against medical advice. Both of them had their PSA drop by 2-3 ng/ml. Are you seeing this in practice? Patients taking ivermectin on their own and then their PSA's drop? Of course, there is concern about toxicity of ivermectin, especially liver toxicity.

Answer from: Radiation Oncologist at Academic Institution

Is this even the right question, though? ADT drops PSA very reliably and yet does not cure patients. Finasteride suppresses PSA, but we do not use it as a mainstay of cancer treatment. Even if ivermectin *did* suppress PSA, unless there is a meaningful oncologic benefit (*at least* reduced recurrenc...

Comments

Radiation Oncologist at The Cancer Center P.C.
Helpful answer. I have patients present me with th...

Radiation Oncologist at Prairie Lakes Healthcare System
Thank you. This topic is coming up more and more o...

Radiation Oncologist at Mallory Radiotherapy, PLLC
In terms of liver toxicity, fenbendazole is my mai...

Answer from: Medical Oncologist at Community Practice

Is there any evidence that ivermectin suppresses the PSA level in prostate cancer?Short answer: No. There is no evidence in the medical literature that ivermectin suppresses prostate-specific antigen (PSA) levels in prostate cancer. Current evidence is limited to preclinical models, and there are no...

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Medical Oncologist at Duke University School of Medicine
I agree, and would also point out that ivermectin ...

Radiation Oncologist at University Of Texas Medical Branch
Although I don't do prostate XRT any longer, I tho...

Answer from: Radiation Oncologist at Community Practice

I have a patient who had a PSA response to self-administered ivermectin and fenbendazole.

Comments

Medical Oncologist at Mary Lanning Healthcare Morrison Cancer Center/University of Nebraska Medical Center Adjunct Faculty
It is important to note that while PSA response is...

Radiation Oncologist at North Cascade Cancer Center
Ivermectin and fenbendazole can modestly lower PSA...

Medical Oncologist at Mary Lanning Healthcare Morrison Cancer Center/University of Nebraska Medical Center Adjunct Faculty
Unfortunately, that approach is totally outside of...

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Is there any evidence that ivermectin suppresses the PSA level in prostate cancer?

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