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Is there any evidence that spironolactone or finasteride therapy increase blood levels of testosterone?

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Does Spironolactone and Finasteride increase testosterone levels?

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2 Answers
Mednet Member
Mednet MemberInvited Expert
Endocrinology · Tufts Medical Center Physicians Organization
Answered on

Yes. It seems that both medications can do this at least in the short term. Spironolactone's effect may be more temporary.

For spironolactone, an older article: Tidd et al., PMID 152681

For finasteride: Stanczyk et al., PMID 23474436

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Mednet Member
Mednet MemberInvited Expert
Endocrinology · Endocrine Care Center At Uw Medical Center Roosevelt
Answered on

Finasteride and dutasteride block 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone. As one might expect, serum testosterone increases, but only modestly (10-20%) in cis-men.

Spironolactone has minimal, if any effects, on serum testosterone i...

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