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Is there any mature data about cognitive outcomes in 12 Gy vs 18 Gy in the setting of prophylactic cranial irradiation for ALL in children?

1 Answer
Mednet MemberInvited Expert
Radiation Oncology · University Hospital Basel
Answered on

There is some data on AML showing some differences between 12 vs. 18 Gy, yet still quite a low incidence.

https://www.ncbi.nlm.nih.gov/pubmed/21480469

4/134 (3%) of patients treated with 12 Gy versus 8/108 (7%) of patients treated with 18 Gy demonstrated behavioral disorders and cognitive impairment. This is what is stated in the paper, but without any specifics and in only around 50% of the patients evaluated.

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