Is there any mature data about cognitive outcomes in 12 Gy vs 18 Gy in the setting of prophylactic cranial irradiation for ALL in children?
1 Answers
Mednet Member
Radiation Oncology · University Hospital Basel
There is some data on AML showing some differences between 12 vs. 18 Gy, yet still quite a low incidence.
https://www.ncbi.nlm.nih.gov/pubmed/21480469
4/134 (3%) of patients treated with 12 Gy versus 8/108 (7%) of patients treated with 18 Gy demonstrated behavioral disorders and cognitive impairment. ...