Is there any outpatient protocol for cisplatin/doxorubicin neoadjuvant chemotherapy for osteosarcoma?  

Not really. The full dose of cisplatin (120 mg/m²) is difficult (not to mention cruel) to deliver as an outpatient, given the need for fluids, antiemetics, and supportive care.

Outpatient administration of cisplatin/doxorubicin (albeit at a slightly reduced cisplatin dosage of 100 mg/m²) protocol is documented in the BC Cancer out in Vancouver, British Columbia. We offer this at Roswell, with the addition of mannitol, but it is a long 8-hour day, and close follow-up i...