Is there any role for additional antiviral therapy during rebound from COVID-19 infection after a course of Paxlovid?

Guidelines treat rebound mostly as an infection control issue requiring additional isolation. Treatment is not routinely recommended. Anecdotally, both in the literature and in my practice, I have encountered patients, mostly immunocompromised hosts with severe or very symptomatic rebounds who have ...

Rebound after a documented case of COVID-19 can occur whether a person has taken Paxlovid or not though it appears to happen more frequently in persons who have taken Paxlovid. It typically occurs within a week after the initial episode and is typically mild. The main concern is shedding of the viru...