Is there any role for radiation in the treatment of stage II nasopharyngeal DLBCL involving bilateral nasopharynx and unilateral cervical nodal involvement but without bony or nerve involvement?

The role of RT in the rx of stage II DLBCL, either nodal or extranodal in type, remains controversial with NCCN guidelines allowing for either approach. There is agreement that initial therapy should be systemic, typically R-CHOP at present. For patients achieving CR (PET-negative), we routinely use consolidation RT and a protocol dose of 20 Gy. While the dose is still considered investigational, our own institutional data (and pending data from an ILROG study) indicate local control greater tha...

Very interesting data concerning the dose of 20 Gy, looking forward to it!