Is there data that shows that late side effects change from 5 year follow up to 10 year follow up when comparing iso-effective doses of conventional and hypofractionation for breast cancer?

Thank you, this is an interesting and relevant question given the emergence, for example, of 5-fraction (26 Gy) whole breast irradiation (WBI) as an option for patients based on 5-year results of the FAST-Forward clinical trial (Brunt et al., PMID 32580883). One of the most rigorous analyses I have seen looking at breast late effects is the RAPID clinical trial comparing twice daily 3DCRT APBI (38.5Gy/10fx) vs WBI (Whelan et al., PMID 31813635). There were paired trained nurse and patient assess...

It is amazing to me that so many of you are eager to jump on the bandwagon of finding the fewest number of treatments for every clinical scenario. In breast cancer, it took the 10-year and 20-year results of mastectomy vs lumpectomy/xrt to make the latter a viable alternative to surgeons in the USA.

And of course, this was with standard fractionation, so out of vogue now.

Who will you get to be your expert witnesses when you are sued by your patients who get a local recurrence, and the prosecuting...