Is there evidence to suggest there is a withdrawal syndrome from muscle relaxants such as tizanidine?
1 Answers
Mednet Member
Psychiatry · McLean Hospital/Harvard Medical School
The answer is yes, there is evidence in published literature supporting withdrawal manifestations from sudden discontinuation of alpha-2 agonists including tizanidine (references below), primarily due to catecholamine surge causing a sympathetic overdrive, affecting the patient's physiological state...