Much has been learned since the cautionary data from Indiana University was published showing increased toxicity when using SBRT for centrally-located lung cancers. One should be aware that there is an increased risk when treating tumors in this location with SBRT fractionation schemes. I am aware ...

There might be a larger teaching opportunity related to the Corradetti report. The patient suffered a fatal complication after a biopsy of the irradiated tissue, a result that is akin to a case reported by the Memorial Sloan Kettering group (Cox et al, IJROBP 83(5):e6617-e667). In the latter example...

I agree with @Jeffrey D. Bradley's comments above.  I have been using 50Gy in 5 fractions delivered every other day for the past 3 years for central lesions.  The main issue is esophageal injury.  I have had 1 or 2 patients develop significant esophageal stricture when the PTV ov...

VU University Medical Center regimen (60 Gy in 8 fxs) or U of Rochester regimen (50 Gy in 10 fxs) are also reasonable. I've using them, especially in re-irradiation setting, without any significant toxicities.

For the proton, I would consider 70 Gy in 10 fractions over 2 weeks. Bush et al reported their 12 years experience using passive scattered proton beam on 111 patients stage T1-2 at Loma Linda University in the Red journal (2013, 86(5) pp 964-968) with excellent local control and safety profile. No...