Is there specific data on using luspatercept for sickle beta+ thalassemia with transfusion-dependent anemia?

The mechanism of action of luspatercept is to trap and remove ligands of the TGF beta superfamily of ligands, specifically the growth and development factors (GDFs) 11 nd 15. This allows more maturation and differentiation of the erythroid precursors, and an increase in red cell production and relea...

Sickle beta+ thalassemia does not typically cause transfusion-dependent anemia. The anemia is usually mild or nonexistent in this SCD variant, so if there is severe anemia, I would investigate for other comorbidities. There is no specific data on luspatercept in any of the sickle cell disease subtyp...

Similarly, I know of no data supporting its use in sickle-beta thalassemia.