Topics:
Gastrointestinal Cancers • Medical Oncology
Is there strong evidence to use TMB found in circulating tumor DNA to guide the use of ICI in metastatic colon cancer?
Answer from: Medical Oncologist at Academic Institution
The benefit of immunotherapy for patients with high TMB was demonstrated in the KEYNOTE 158 study (Marabelle et al., PMID 32919526). This is a phase 2 study that enrolled 1076 patients with advanced solid tumor (a total of 10 different tumor types including anal, biliary, cervical, endometrial, meso...
Sign in or Register to read more
Answer from: Medical Oncologist at Community Practice
Circulating tumor DNA has a consistently higher TMB than tissue. As noted by Dr. @Jin, MSKCC has demonstrated (Rousseau et al., PMID 33761214) no benefit for patients that are not MSI-H or POLE/POLD mutated (specific domain of polymerase also to generate the hypermutation phenotype) metastatic CRC p...