Is there therapeutic relevance for FLT3-ITD mutation in relapsed APML?
Patient has a second relapse post alloHCT for high risk APML
Community PollStarted
Would you incorporate a FLT3 inhibitor with your reinduction/salvage regimen in FLT3 mutated APML?
16 physicians have voted
Join Mednetto vote and see how they answered.
1 Answer
Mednet MemberInvited Expert
Hematology · University of Chicago
Answered on · Updated on
FLT3-ITD mutations are seen in anywhere from 12-38% of APL cases, and there are conflicting data on the prognostic impact of the mutation on outcomes (Kuchenbauer et al., PMID 16029447, Beitinjaneh et al., PMID 20096459, Kiyoi et al., PMID 9305596, Kainz et al., PMID 12522450, Schnittger et al., PMI...
Join for free or sign in to see the full answer