Is there utility in administering adjuvant chemotherapy to a patient with relapsed osteosarcoma for whom CR2 is achieved after surgical resection alone?

Multiple trials have attempted to improve DFS/OS by implementing adjuvant chemotherapy or targeted agents in this scenario. All of these trials have been NEGATIVE.

There is no evidence to support the use of adjuvant chemotherapy in patients who achieve complete surgical response after relapse.

Nonetheless, patients, families & providers understandably feel the need to do SOMETHING in these situations, but all data thus far suggests that systemic intervention results in adverse effects without an...