Is weekly Cisplatin considered a valid alternative to Cisplatin cycles every 3 weeks as part of definitive chemo-radiation for muscle invasive bladder cancer?

None of the RTOG trials had this approach, but extrapolating from head and neck cancer (cisplatin 30mg/m2) or cervical cancer (40mg/m2), people in the community are using weekly cisplatin. As far as data, there is a phase II study from Australia utilizing cisplatin 35mg/m2 weekly for 6-7 cycles showing efficacy and it will be the schedule used in upcoming phase III trials. There is also a phase II trial from Morocco in abstract form.

http://www.ncbi.nlm.nih.gov/pubmed/17011058

http://meeting.ascopubs.org/cgi/content/abstract/26/15_suppl/16109