Arthritis care & research 2012-10
2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia.
Related Questions
If a patient who has tolerated allopurinol for a prolonged period of time is subsequently found to be positive for the HLA-B*58:01 gene, how would you manage urate-lowering therapy thereafter?
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2 Answers
Mednet Member
Rheumatology · National institues of Health
There is a strong association between the presence of the HLA-B*58:01 allele and allopurinol-related severe cutaneous adverse reactions (SCAR* - Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis or Severe Hypersensitivity Syndrome). This association was demonstrated in a Taiwanese study by Hung e...
Is febuxostat a safe alternative for patients who are HLA-B*58:01 positive and of Han Chinese descent?
1 Answers
Mednet Member
Rheumatology · National institues of Health
Cutaneous reactions to allopurinol range from the mild to the very severe and life-threatening such as Stevens-Johnson's Syndrome (SJS) and toxic epidermal necrolysis. The association of these reactions is so strong as to have its own acronym, AHS, for the allopurinol hypersensitivity syndrome.These...