Int. J. Radiat. Oncol. Biol. Phys.
A randomized study comparing two high-dose per fraction radiation schedules in recurrent or metastatic malignant melanoma.
ABSTRACT
Thirty-five tumors in 14 patients with metastatic or recurrent malignant melanoma were randomized to high dose per fraction radiotherapy at either 9 Gy X 3 or 5 Gy X 8 twice weekly. Complete and persistent regression was found in 24/35 (69%) and partial response in 10/35 of the tumors. The overall response rate was 97%. No difference was observed between the two treatment regimens. Acute and late radiation damage to normal tissue was acceptable and of the same magnitude in both schedules.
Related Questions
In this case, I have a patient with widely metastatic cutaneous melanoma (BRAF wild type, NRAS mutated) who is progressing through pembrolizumab and i...
New comment by Radiation Oncologist at Mon Health ( January 29, 2022)
Thank you, what are your thoughts about 6 Gy x 5, every other day for a bleeding anorectal melanoma?
Specifically, for a melanoma of the axilla with proximity to the brachial plexus, how would you approach such a case to minimize chance of radiation-i...
New answer by Radiation Oncologist at Memorial Sloan Kettering Cancer Center (May 19, 2020)
If the concern is to minimize the chance of radiation-induced brachial plexopathy, then it is advisable to keep the equivalent total dose below the tolerance of the brachial p...