Clin Colorectal Cancer 2018 Oct 10

Bolus 5-fluorouracil (5-FU) In Combination With Oxaliplatin Is Safe and Well Tolerated in Patients Who Experienced Coronary Vasospasm With Infusional 5-FU or Capecitabine.

Related Questions

How would you manage a patient with anal squamous cell carcinoma and 5 FU induced coronary vasospasm 36 hours after starting definitive chemoradiation?

Medical Oncology · Dana-Farber Cancer Institute

I would seek the assistance of an oncocardiologist, if available. Did the patient develop EKG changes? Troponin leak? For coronary vasospasm induced by 5FU, there is a range of severity and risk. Given that this patient only requires a second dose of 5FU, I would see if there were any possibility of...

How would you approach the management of newly diagnosed metastatic colon cancer in a patient who experienced infusional 5FU-related cardiotoxicity with initial chemotherapy?

1 Answers

Mednet Member

Medical Oncology · Advocate Lutheran General Hospital

I have a patient who developed documented coronary spasm with EKG changes and troponin elevation on 5 FU infusion, given as part of FOLFOX cycle 1, 3 weeks ago. She is now on the FLOX regimen with Isosorbide mononitrate and amlodipine prescribed by cardiology with specific dosing and timing recommen...