JAMA Oncol 2016 Mar
Delayed Initiation of Adjuvant Chemotherapy Among Patients With Breast Cancer.
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How would you approach timing of adjuvant chemotherapy in a Stage 1 TNBC lost to follow up for >1 month since surgery?
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Mednet Member
Medical Oncology · Yale School of Medicine
Delayed initiation of adjuvant chemotherapy beyond 60-90 days has been linked to inferior outcomes in several studies (see for example Chavez-MacGregor et al., PMID 26659132). However, if this worse outcome is primarily due to time delays in chemotherapy or driven by other variables (e.g. ability to...
How do you sequence radiation and capecitabine in breast cancer patients receiving adjuvant capecitabine for residual disease after neoadjuvant chemotherapy?
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Radiation Oncology · Mayo Clinic, Rochester, MN
According to personal communication with Dr. Masakazu Toi (June 13, 2017), the corresponding author of the CREATE-X NEJM publication, radiotherapy was administered prior to capecitabine in the majority of cases on this study. It is worth noting that in CALGB 49907, a randomized trial comparing capec...