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JAAD Case Rep 2019 Oct 10

Dual biologic therapy for recalcitrant psoriasis and psoriatic arthritis.

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Would you consider using a JAK inhibitor in combination with an IL 23 inhibitor in cases of severe psoriasis, psoriatic arthritis, or axial spondyloarthritis that is refractory to multiple biologic DMARDs?

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Mednet Member
Mednet Member
Rheumatology · University of Wisconsin Madison

Differential skin and joint responses in psoriasis, PsA and Axial SpA are not uncommon. Many PsA/PsO experts and scientists have postulated the potential benefit of using combination biologic (perhaps in serial fashion or lower doses of each) to treat these cases where there are suboptimal responses...