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Clinical oncology (Royal College of Radiologists (Great Britain)) 2020 Jul 11

Hypofractionated Accelerated Concurrent Chemoradiotherapy in Inoperable Stage III Non-small Cell Lung Cancer: SOCCAR. A Large Single-Centre Experience.

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Related Questions

Would you offer any degree of hypofractionation with concurrent chemotherapy for NSCLC?

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4 Answers
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Radiation Oncology · Mayo Clinic Florida

I typically wouldn't, given limited data. CALGB 31102 (phase 1 trial) looked into this and found the maximal tolerated dose (MTD) to be at 60 Gy in 24 fractions (i.e., 2.5 Gy/fx). There's another phase 1 trial from Wisconsin which showed similar results (i.e., 2.5 Gy/fx). With these results in mind,...