Major Adverse Cardiovascular Events and the Timing and Dose of Corticosteroids in Immune Checkpoint Inhibitor-Associated Myocarditis.

Circulation 2020 Jun 15

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For patients on immune checkpoint inhibitors presenting with chest pain, dyspnea, fatigue, and troponin elevation, would you recommend early initiation of high dose steroids for empiric treatment of ICI myocarditis while pursuing workup with coronary angiogram, echocardiogram, and/or cardiac MRI, or wait until alternative etiologies have been ruled out?

New comment by at FibroFighters Foundation ( June 29, 2023)

Do you use tocilizumab? Or only if steroids fail? I ask because tocilizumab has anti-cancer properties and can promote IL-12 - which enhances immune-mediated cancer effect, w...

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