Multicenter Phase II Clinical Trial of Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for Patients With High-Grade Upper Tract Urothelial Carcinoma.

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Medical Oncology · University of California Los Angeles, Los Angeles

UTUC has different biology from MIBC and is considered more aggressive. Patients with UTUC were excluded from the NIAGARA, and therefore, we cannot make assumptions and extrapolations. Having said that, in patients with UTUC, it is important to check if they have microsatellite instability or Lynch ...

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Medical Oncology · VCU Massey Comprehensive Cancer Center

Neoadjuvant chemotherapy (NAC) conceptually makes sense in UTUC. A number of retrospective studies showed improved surgical and oncologic outcomes with NAC in UTUC. A recent phase 2 clinical trial (Coleman et al., PMID 36603175) confirmed this (63% pathologic response, improved PFS and OS) using spl...