BMJ 2016 Sep 30

Revisiting the drug interaction between tamoxifen and SSRI antidepressants.

Related Questions

In a premenopausal woman with low risk, early stage HR-positive breast cancer who is unable to discontinue a strong CYP2D6 inhibitor, do you use still utilize tamoxifen versus an AI with ovarian suppression?

Medical Oncology · Icahn School of Medicine at Mount Sinai

CYP2D6 enzymes metabolize tamoxifen to the active metabolite endoxifene. There are variants alleles of the the 2D6 enzyme such that depending on the inheritance of one or two variant alleles one makes less endoxifene. Testing for variant alleles is clinically available, however, the results of studi...