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Pediatric blood & cancer 2023 Feb 11

Sodium thiosulfate as cisplatin otoprotectant in children: The challenge of when to use it.

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For what patients/diagnoses do you currently use sodium thiosulfate to reduce the risk of cisplatin associated ototoxicity?

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Pediatric Hematology/Oncology · Children's Hospital Los Angeles

Sodium thiosulfate (STS) is approved in the US (FDA) and Europe (EMA) for the prevention of cisplatin-induced hearing loss (CIHL) in patients 1 month and older treated with cisplatin for any type of cancer. Although intravenous STS has not been subjected to a randomized clinical trial for patients >...