Treatment patterns for AL amyloidosis after frontline daratumumab, bortezomib, cyclophosphamide, and dexamethasone treatment failures.

Mednet Member

Medical Oncology · Mayo Clinic Rochester

Achieving an early hem deep response (at least VGPR or better) is crucial for organ response and has demonstrated OS benefit.I would favor changing treatment even by cycle 4 if the hematologic response is <PR. Early switch in such situations led to improved EFS and better chances for an organ respon...