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What is your approach to elevated CK in patients without clinical or serologic evidence of immune mediated myopathy?

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1 Answers

Mednet Member
Mednet Member
Rheumatology · Emory University

Thanks for your great question: This is especially important because we are much more likely to see patients sent for "elevated" CPK than patients with myositis.Unfortunately, I think that the answer to the approach depends a lot the circumstances, including (1) how elevated is the CPK, and (2) how ...

What is the negative predictive value of a negative extended myositis panel in dermatomyositis patients?

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2 Answers

Mednet Member
Mednet Member
Rheumatology · Emory University

The short answer is "not great, but it depends" since the more nuanced answer is contingent on: the constellation of myositis-specific antibodies (MSA) included on the panel, the nitty-gritty of how the commercial lab is checking the MSA included (this detail can change between vendors, or even ...

Is nailfold capillaroscopy useful for prognostication and evaluation of disease progression in MCTD/myositis patients?

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1 Answers

Mednet Member
Mednet Member
Rheumatology · Emory University

Great question for clinicians: Nailfold capillaroscopy is useful for several systemic autoimmune diseases and, not surprisingly, multiple studies have documented frequent nailfold capillary abnormalities in patients with multiple types of autoimmune myositis, including dermatomyositis (DM), anti-syn...