Should a different weight-based dosing algorithm for levothyroxine therapy be considered in women versus men given higher incidence of iatrogenic thyrotoxicosis in women?

I do not.

For the majority of my patients, my starting dose is 1.6 mcg/kg, which is in the ATA guidelines (1.6-1.8 mcg/kg has been recommended as the starting dose in many publications). There have been some studies that show using ideal body weight is a better predictor of LT4 dose, and others that say lean body mass is even better (as this study also noted). The problem is that lean body mass is not available for many patients, but there are estimation calculators; note that ideal body weight calculators are readily available. Unfortunately, many of the ideal body weight calculators vary in their calculation, and can actually increase the weight for patients on the lower end of the normal BMI spectrum.

For patients over the age of 60, o...