Topics:
Hematologic Malignancies • Pediatric Oncology • NCI-CCC Tumor Board Question • CML • AYA Tumor Board • Nationwide Children's
Should a teenager diagnosed with CML in blast crisis go to transplant once MRD is negative?
Answer from: at Community Practice
I would take the patient to BMT now. Survival of patients who received BMT for blast crisis is dependent on the pre-BMT remission status (Radujkovic et al., PMID 31271884), but I am not aware of data showing benefit of giving consolidation when a patient has negative MRD. Best results of BMT are ach...
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Answer from: at Academic Institution
Usually, the goal of initial management of CML blast crisis is to revert to chronic phase, with plans to proceed with allogeneic hematopoietic cell transplantation (HCT) in chronic phase, if possible. If the presentation was blast crisis without previous TKI, then I will start with TKI alone an...