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Should an individual who received the purified protein Hepatitis B vaccine in 1985 receive a booster or have antibody titers checked?

1 Answers
Mednet Member
Mednet Member
Hepatology · University of Pennsylvania

I recommend you ask yourself two questions.

  1. How likely has this individual lost humoral immunity? Did they receive B cell deplaning chemotherapy or have CLL, etc?
  2. How likely is the individual to be re-exposed?

If the answer to both is low, re-vaccination probably provides no benefit.

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Should an individual who received the purified protein Hepatitis B vaccine in 1985 receive a booster or have antibody titers checked? | Mednet