Should consolidative RT for extensive stage SCLC be given before, after, or concurrently with PCI?
Great question, and to my knowledge there's not a lot of data to guide this so I dont think there's a wrong answer.
Before the CREST trial, my practice was to do PCI first, because I felt that the evidence for an OS benefit was much stronger, and it was therefore more improtant to get this completed ...
In the extensive disease setting, I have been doing PCI and thoracic radiation concurrently if the patient wants both. But frequently once I present the controversy of PCI in the extensive disease setting, the patient chooses just to have thoracic radiation. I feel very ambivalent about PCI for exte...
For a change, I can agree with the above. CREST disappointed. It did *NOT* improve one year survival. TRT seemed to have no benefit in those that achieved a CR! I've not heard update on 2014 Japanese trial attemptong to undo the strong results Slotman published for PCI in SCLC. To me, the PCI data a...
If we offer PCI and thoracic RT we do it concurrently
We also tend to do concurrent PCI and thoracic RT in patients with good performance status.