Should GLP-1 agonists be held during chemotherapy?

3 Answers

Mednet Member

Endocrinology · Brigham And Womens Hospital Endocrinology

I think there are several aspects to this question.

First, is there evidence that as a class GLP-1 RAs increase the risk of cancer or worsen prognosis during cancer? I could find nothing to raise concerns about outcomes. One recent report even showed a decreased risk of some cancers with GLP-1 RA co...

Mednet Member

Medical Oncology · University of Michigan Medical School

No. GLP-1 receptor agonists do not need to be held during chemotherapy, and there could be some benefit for these agents. For example, semaglutide is being studied in a randomized trial for mucositis prevention in BM transplant patients. [Sørum et al., PMID 39384243]

In general, these agents are well...

Mednet Member

Endocrinology · Private Pratice

When a patient experiences a significant change in their health status, it's essential to re-evaluate the risk-benefit balance of their prescribed GLP-1RA therapy. Key factors to consider include:

Continued Need: Does the patient still have a clinical indication for GLP-1RA treatment?
Tolerability:...