Should mRS be incorporated into determining eligibility for extended window thrombolysis?

Key thrombolysis trials (WAKE UP, OPTION, EXTEND, TIMELESS, ECASS-4, HOPE, EXTEND IA) excluded patients with mRS of 2 or greater. The reason for this was the outcome of functional independence at 90 days. Hence, for trial purposes, to look at the outcome, it was necessary to exclude patients with di...

I would re-phrase the question and ask if the pre-morbid status of the patient should be considered prior to stroke thrombolysis in any time window, early or late?

First the mRS is an outcome scale and not designed to assess pre-treatment status. It is designed to assess post-stroke outcome. It is b...