Should neoadjuvant chemoradiation ever be considered in the a patient with high risk rectal cancer in the setting of active ulcerative colitis?

Yes, several studies (admittedly virtually all are single institution and retrospective) suggest the risks of toxicity from radiation in the setting of UC or Crohn's are not as high as many of us previously believed. I think it is prudent to discuss the potential risks of excess toxicity with the pa...