Should patients starting cyclophosphamide be screened routinely for latent tuberculosis (TB)?  

Yes, I think patients starting Cyclophosphamide should be screened routinely for latent TB since CYC is a strong immunosuppressant and increases the risk of TB reactivation. The issue is that CYC is often being considered for life or organ-threatening situations, for which it may not be ideal to wai...

I certainly believe that latent TB could reactivate due to a multitude of immunosuppressive drugs, including TNF inhibitors. Drugs such as cyclophosphamide, azathioprine, mycophenolate mofetil, and corticosteroids could pose a greater risk.